Infrastructural initiatives 2017

vrouwelijke onderzoeker in een laboratorium

Projects funded in call 2017-I

Number of pre-proposals submitted 40
Number of proposals invited for full submission  12
Number Infrastructure Initiatives granted  7

The Infrastructure initiatives proposals were evaluated  by a multidisciplinary evaluation committee composed by selected members of the internal review committee of the KWF Advisory Board and external (inter)national experts. 

Funded projects

Facilitating power: collecting and managing international data on (rare) colorectal cancer predisposition syndromes
PI: M. Nielsen, LUMC
Funding granted:  45.560

This infrastructure initiatives deals with data collection of data on rare colorectal  cancer pre-disposition syndromes and will provide uniform data collection of MSH6, PMS2 and MAP families in the Netherlands. The resulting databases can be used for cancer risk analysis and risk modifier studies, which will be become part larger international initiatives as International Mismatch Repair Consortium (IMRC) and IMC International MUTYH Consortium (IMC).

GENONCO: GENomics portal for precision medicine research in ONCOlogy
PI E. Cuppen, HMF
Funding granted: 1.600. 778

The aim of GENONCO is to create linkages between HMF data and other data resources and thus provide the researchers with easy access to multimodal and complementary data resources including the  HMF genomic database. In this context, GENONCO will evolve around the FAIR data principles contributing to findable, accessible, interoperable and re-usable data.

CustoMICE: a facility for production and distribution of engineered mouse models for  cancer research
PI: J. Jonkers, NKI
Funding granted: 866.548  

CustoMICE aims at the generation and distribution of mouse models for basic and translational cancer research and immuno-oncology. In addition to the  development of novel methods for mouse engineering and refinement of  existent ones, CustoMICE will aim at  improving the efficiency in mouse generation and thereby contributing to the 3Rs  by methodology refinement and  reduction in the number of animals.

ProTRAIT: Proton therapy research infrastructure
PI: J. Langendijk, UMCG
Funding granted: 1.545.098 

The aim of this infrastructure initiative is to develop and implement a national research infrastructure for radiotherapy-specific data of cancer patients who are treated with proton and photon irradiation. Further the  IT infrastructure  developed will  streamline the use of clinical parameters, the assessment of radiation-induced complications and Patient Reported Outcome Measures (PROMs) at a national level.

The BETER-REFLECT biobank: A REsource For studies on Late Effects of Cancer Treatment
PI: F. van Leeuwen, NKI
Funding granted: 938.338

The aim of the BETER-REFLECT Biobank is  to establish a national biobank with biospecimens and related data from medical records and patients questionnaires of all the lymphoma survivors identified through the BETER Consortium.

The development of a Dutch Hepatocellular Carcinoma Group (DHCG) national scientific database and biobanking
PI: M Coenraad, LUMC
Funding granted: 440.251

This infrastructure will enable research aimed at the development of new biomarkers for the detection of early hepatocellular carcinoma and the   optimization of  treatment strategies, by the development of a   biobank  and database.

Netherlands Facility for Cancer-Immune Analysis (N-CIA)
PI: T. Schumacher, NKI
Funding granted: 3.648.008
This infrastructure initiative aims at providing a nationally accessible infrastructure for standardized  analyses of a wide collection of parameters relevant to immune mediated tumour-control and therefore N-CIA will support the standardized sampling of tumour and blood of metastatic cancer patients.

Infrastructure Initiatives funded in the course of 2017

TraIT in transition to Health-RI 
DORP:  Dutch Oncology Research Platform